December 3, 2562 BC â€” The novel “Aarahar” was written by K.R. Mirai and. originally published in serialized format in Malayalam. magazine in 53 volumes and . July 30, 2014 – The novel “Aarahar” was republished in .
This time the novel has been revised in order to comply with the rules of Hindi and English.
The book was published in .
January 18, 2015 – The novel “Aarahar” was published in .
The publication included comments on it.
The book was published in Delhi by a publishing house.
December 3, 2018 – The Aarahar novel was re-released in .
A commentary has been added to the publication, as well as an English translation.
The book was published by .
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^”Chhattisgarh mine accident”. Economic Times. Retrieved November 11, 2013. âAt least eight miners were killed and more than 20 were trapped in Fridayâs accident in a coal mine in Raigarh area in Chhattisgarh. Seven others were rescued and sent to Raipur-based Nizamuddin Hospital. Injured were taken to Rizwan Memorial Hospital in Raipur.In vivo anti-myeloma activity of a novel first-generation bispecific antibody.
The high frequency of malignant plasma cell clones in multiple myeloma (MM) requires the development of monoclonal antibodies (mAbs) targeting the underlying malignant plasma cells. Based on encouraging preclinical data, a novel mAb, MGA271, was developed against myeloma cells, and termed bispecific antibody (BiFab), which binds simultaneously to myeloma cells and to the α4β7 integrin. In this study, we further characterized the in vivo anti-myeloma activity of MGA271 and its Fc-engineered variant, Fc?. Both molecules exhibited a strong in vivo effect on tumor growth of multiple myeloma cell lines and primary myeloma patient-derived xenografts in SCID mice, whereas the effect on lymphoma growth was significantly lower. Notably, Fc? significantly prolonged survival of mice with advanced stage MM. Similar to MGA271, Fc? also recruited NK cells to the tumor sites, and this was accompanied by upregulation of the activating receptor NKp30