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The use of polyurethane to coat medical devices is by far the most frequent. The coatings typically comprise a polyurethane prepolymer that includes a diisocyanate as a hardener, a polyol as a polyol component, and various other additives (either as polyol or additive components). The coating is applied to the device by dipping or spraying and is cured (polymerized) by reaction between the diisocyanate and the polyol.
Polyurethane coatings are not as effective as polyethylene or other non-hydrolytic polymer coatings in preventing the adherence of microorganisms, such as Staphylococcus aureus (S. aureus) or Pseudomonas aeruginosa (P. aeruginosa), to devices. Hydrolytic polymer coatings have been used for this purpose, but their biocompatibility is generally inferior to that of non-hydrolytic polymers.
The use of polyisocyanate-based polyurethanes (PUs) to coat implantable medical devices is well-documented
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Perioperative nursing of neurosurgical patients is challenging. Perioperative pain, nausea and vomiting, cognitive impairment and delirium are the most important problems in these patients. Pain assessment and management, sedation and delirium therapy, fluid therapy and oxygenation are also main concerns