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Category: Microsoft Office
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Category: DictionariesPharmaceutical drug discovery has long been driven by the observation that compounds having certain structural features are more active and/or less toxic (and therefore potentially better drug candidates) than others. The ability to rationally predict, from the structural features of a drug candidate (e.g., those features contained in the molecular structure of the drug candidate), those compounds that have good pharmaco-kinetic and -dynamic properties would constitute a significant step forward in pharmaceutical drug discovery.
One of the best known standard approaches to quantifying the therapeutic value (or lack thereof) of a compound is known as the “5-HT3 receptor antagonist activity and toxicity profile”. One method for assessing the therapeutic value of a compound is to examine the electrophysiological activity of this compound, at a 5-HT3 receptor expressed in Xenopus laevis oocytes, as described in WO-A-95/06714. However, this approach is relatively tedious, time consuming and requires the use of relatively high concentrations of the compound (100-200 μM) in order to monitor the effects of the compound on 5-HT3 receptor function.
An alternative method for examining the therapeutic value of a compound is to examine the concentration dependency of the compound, at a 5-HT3 receptor. Using this method, the therapeutic value of a drug candidate may be quantified, for example, by screening a plurality of concentrations of the drug candidate and selecting the concentration(s) at which the drug candidate has the most potent pharmacological activity. Furthermore, this method provides a real quantitative measure of the therapeutic value of the candidate compound, rather than only a qualitative measure (e.g. “active” or “inactive”), as is the case with other conventional methods.
However, this method has proven to be difficult to perform. In particular, the requirement that the drug candidate be examined in a plurality of concentrations means that it is necessary to determine the concentration-response relationship for many different concentrations of the drug candidate. However, as described in EP-A-0179299, the concentration-response relationship for a given compound is often not linear. As a result, as the concentration is increased, the compound’s response may


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: Tissue-type plasminogen activator

The authors would like to thank all participants, physicians and nurses for their contributions.

Funding {#FPar1}

This work was supported by the grants from European Union 7th framework program (DEXHEALTH; HEALTH-F4-2008-202,645).

Availability of data and materials {#FPar2}

The datasets during and/or analysed during the current study available from the corresponding author on reasonable request.

Authors’ contributions {#FPar3}

TO, AK, SP, MJS and LK conceived and designed the trial. SP, GO, TO and MJS designed and planned the biopsy taking. GO, LD and TO planned the laboratory analysis. GO, SP and LK wrote the manuscript. AK and SP drafted the manuscript. All authors read and approved the final manuscript.

Competing interests {#FPar4}

The authors declare that they have no competing interests.

Consent for publication {#FPar5}

Not applicable.

Ethics approval and consent to participate {#FPar6}

The study was approved by the Ethics Committee of the Medical Faculty of the University of Erlangen-Nürnberg (date of approval 16/07/2012), and informed consent was obtained from each patient before inclusion in the study.
1. Field of the Invention
The invention relates to a method and apparatus for data compression and decompression in a high speed tape stream controller.
2. Related Art
Tape drives are used for recording data to and retrieving data from magnetic tape. In a read/write tape system, the tape drive must read and write data that is recorded in packets on the magnetic tape. The packetized format enables more than one data



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